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I have seen no evidence indicating that Sinemet per se becomes ineffectual with time. I am convinced that the dosage of Sinemet is increased as the disease progresses to a point that there may not be sufficient neurons to be activated by any amount of L-dopa. At that point, the PWP is frozen, bed-ridden or in a wheel-chair to be totally cared for. Michel Margosis > Tony Schoonenberg wrote: > I just read the latest in the continuing saga of the war against > Parkinson’s patients, that’s right not Parkinson’s disease. Be > sacrificed at the alter of neuroscience. This is in response to > the recently published article by " J Neurology Neurosurgery > Psychiatry 1999 Sep; 67 (3): 300-7". The premise of this paper > has to do with the fact that we are told by the neurology > community that Sinemet is toxic and should be limited. Everyday > as patient advocate I see the suffering resulting from this > fallacy, but this flawed opinion persists ......................