 |
 |
On Wed 16 Feb, Nigel Harland wrote: > Hi Ivan, > I'm afraid my source is pretty vague, my mother who is the > secretary > of our local PD Society had been told about it by a friend, who had read > about it in a Medical Journal, however, Barbs' message seems to have > confirmed it !! > Regards, Nigel > ----- Original Message ----- > From: Ivan M Suzman <[log in to unmask]> > To: <[log in to unmask]> > Sent: Wednesday, February 16, 2000 8:41 AM > Subject: Re: Dopamine patches? > > > > Hi Nigel, > > > > Who iis your source? > > Thanks > > Ivan > > > > On Wed, 16 Feb 2000 03:23:36 -0500 Nigel Harland <[log in to unmask]> > > writes: > > >Hello all, > > > I have heard an unsubstantiated rumour that Dopamine > > >Patches are soon to be released by Roche, can anyone verify this ? > > >Thanks, > > >Nigel 45 diagnosed 12 yrs ago. > > > > ^^^^^^ WARM GREETINGS FROM ^^^^^^^^^^^^ :-) > > Ivan Suzman 50/39/36 [log in to unmask] :-) > > Portland, Maine land of lighthouses deg. F :-) > > ******************************************************************** > > > > > I am sorry to be the bearer of bad news, but the excitement at the news of imminent release of Dopamine patches is a little premature. The last time that I checked up on this subject the outcome was as follows: 1/ Dopamine patches would not work, because the Dopamine would be attacked and destroyed before it could travel from the patch to the brain. 2/ A levodopa patch would take care of the destruction while the chemical was in transit, but there is another factor which over-rides points 1 and 2. That is: 3/ Levodopa and Dopamine are such large molecules, and we need it in such large quantities, that I doubt if you could could get the flow rate required even if you used a full body patch!! (What an apalling thought) 4/ I think you will find, it you scan the press releases which have been issued from time to time the magic word 'agonist' lurking quietly in the release. I can't help wondering what is the point of a Dopamine Agonist patch, when the dopamine agonist tablets have such a long half-life that in the case of Cabergoline for instance you only take one per day anyway!! Regards -- Brian Collins <[log in to unmask]> (60/39/34)