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Hi Brian and all others... Here is the web site for the clinical study... http://clinicalstudies.info.nih.gov/detail/A_99-N-0104.html ******************************************************* On 17 Feb 00 at 13:56, Brian Collins wrote: > I am sorry to be the bearer of bad news, but the excitement at the news > of imminent release of Dopamine patches is a little premature. The last > time that I checked up on this subject the outcome was as follows: > > 1/ Dopamine patches would not work, because the Dopamine would be > attacked and destroyed before it could travel from the patch to the > brain. > > 2/ A levodopa patch would take care of the destruction while the chemical > was in transit, but there is another factor which over-rides points 1 > and 2. That is: > > 3/ Levodopa and Dopamine are such large molecules, and we need it in such > large quantities, that I doubt if you could could get the flow rate > required even if you used a full body patch!! (What an apalling thought) > > 4/ I think you will find, it you scan the press releases which have been > issued from time to time the magic word 'agonist' lurking quietly in > the release. > > I can't help wondering what is the point of a Dopamine Agonist patch, > when the dopamine agonist tablets have such a long half-life that in > the case of Cabergoline for instance you only take one per day anyway!! > Regards > > -- > Brian Collins <[log in to unmask]> (60/39/34) > all the best ............. murray [log in to unmask]