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The term porphyrias refers specifically to a group of diseases in which cells in the liver and bone marrow are unable to properly carry out all the steps involved in making heme, due to an inherited defect. The acute porphyrias always display neurological symptoms affecting the central, peripheral and/or autonomic nervous system. These include abdominal pain, nausea, vomiting, constipation, seizures, headaches, difficulty concentrating, personality changes, weakness and aching in muscles and joints, unsteady gait, poor coordination, numbness/tingling of arms and legs, retaining fluids, rapid heart rate, increased blood pressure, increased sweating, and intermittent fever. http://www.mcsrr.org/factsheets/porphyri.html Airline Workers complain of headaches, impaired motor skills, blurred vision, nausea, dizziness, metallic taste in the mouth, mental confusion and or impaired congnitive ability, muscle twitching or tremors, and respiratory difficulties. Tellurium Toxicity : central nervous system, red blood cell changes, garlic breathing, sweating, dry mouth, metallic taste, somnolence, sleepiness, unnatural drowsiness, anorexia, nausea, dermatitis.(seborrhea?) 1. Manganese Toxicity prevents iron from reaching ferrochelatase and causes Parkinsons Disease. 2. MPTP, (pyridine) inhibits porphyrin that takes the iron from ferrochelatase and causes Parkinsons Disease. 3. Tellurium can replace sulfur in the 2Fe-2S cluster of ferrochelatase. 4. Porphyrin is used to make heme. [log in to unmask]