 |
 |
Janet, et al... WAAAAA! When I had my 10/94 unilateral pallidotomy, by the 6-week post surgery doctors visit I'd gained 25 pounds. I COULDN'T BELIEEEEVE IT! The fact that for the first time in 19 years (out of a total of 25 years liivng with PD) I was able to move freely, toss and turn when sleeping, walk normally, and had no dyskenesia whatsoever meant NOTHING to me as them pounds mounted up (well, that's not actually true, but I DO have my priorities, and weight gaining REALLY isn't and wasn't one of 'em!) <Oh vanity, thy name is Barbara> (grin) It took me five, count 'm, FIVE years to lose the majority of that weight and I 've never had to work so hard in my entire life sweating it off! YIKES! I wonder what happens if one has two pallidotomies some months apart/ Is there a DOUBLE weight gain? <shuddering at the thought> Barb Mallut [log in to unmask] -----Original Message----- From: janet marie paterson <[log in to unmask]> To: [log in to unmask] <[log in to unmask]> Date: Friday, February 25, 2000 3:44 AM Subject: PMID: 10685852: Weight gain after unilateral pallidotomy in PD >Weight gain following unilateral pallidotomy in Parkinson's disease. > >OBJECTIVE: To determine the clinical correlates and infer pathogenesis of weight gain following pallidotomy in patients with Parkinson's disease (PD). > >BACKGROUND: Surgical ablation of the globus pallidus internus (GPi) improves levodopa induced dyskinesias, moderately improves most other "cardinal" manifestations of PD, and has been noted to result in increased weight. > >METHODS: We incorporated Unified Parkinson's Disease Rating Scales (UPDRS) subscales, the Beck depression inventory and feeding questionnaire data into a linear regression model in order to determine which post-surgical change(s) may lead to weight gain over the first year following pallidotomy, n = 60. > >RESULTS: The mean weight gain 1 year after pallidotomy was 4.0 +/- 4.1 kg. Improvement in "off" motor scores (P < 0.005), especially gait subscores (P<0.0001), and to a lesser extent improvement in "on" motor scores (P<0.05) predicted weight gain. > >Changes in dyskinesia ratings, mood, food intake, dysphagia, levodopa dose, weight loss in the year prior to pallidotomy, age, and duration of PD did not correlate with subsequent weight gain. > >CONCLUSION: The high correlation between post-pallidotomy weight gain and "off" motor scores, suggests that this phenomenon is related to some change in underlying homeostasis associated with changes in the cardinal manifestations of PD itself, rather than secondary changes resultant from the surgery. > > >Acta Neurol Scand 2000 Feb;101(2):79-84 >Ondo WG, Ben-Aire L, Jankovic J, Lai E, Contant C, Grossman R >Department of Neurology, Baylor College of Medicine, Houston, Texas, USA. >PMID: 10685852, UI: 20148288 > >http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db= PubMed&list_uids=10685852&dopt=Abstract > >janet paterson >52 now / 41 dx / 37 onset >a new voice: http://www.geocities.com/janet313/ >613 256 8340 PO Box 171 Almonte Ontario Canada K0A 1A0