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Impaired novelty detection and frontal lobe dysfunction in Parkinson's disease. Recent evidence suggests that the frontal lobe plays an important role in an orienting response to novel events, and that frontal lobe dysfunction is linked to attentional and cognitive deficits in Parkinson's disease (PD). We tested the hypothesis that the neural network involved in novelty detection may be impaired in PD patients by studying event-related brain potentials to target and novel stimuli and their correlation to performance in neuropsychological tests in non-demented PD patients. The PD patients showed prolonged P3 latency to novel stimuli compared with age-matched controls, whereas their P3 latency to target stimuli was not different from that in controls. The PD patients also manifested amplitude reduction and less habituation of the P3 to novel stimuli over frontal scalp sites compared with controls. The prolonged latency and frontal reduction of novelty P3 correlated with a poor performance in the Wisconsin Card Sorting Test. These results suggest that the orienting response of PD patients to novel events is impaired and that recording novelty P3 might provide a neurophysiological and quantitative measure of attentional and cognitive deficits linked to the frontal lobe in non-demented PD patients. Neuropsychologia 2000 May 1;38(5):645-654 Tsuchiya H, Yamaguchi S, Kobayashi S Department of Internal Medicine III, Shimane Medical University, Izumo, Japan PMID: 10689041 <http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10689041&form=6&db=m&Dopt=b> janet paterson 52 now / 41 dx / 37 onset a new voice: http://www.geocities.com/janet313/ 613 256 8340 PO Box 171 Almonte Ontario Canada K0A 1A0