<snip>Interestingly, while studies
continue to elucidate cellular and
molecular events occurring in the brain in AD and PD, recent data suggest that
both AD and PD can manifest systemic alterations in energy metabolism (e.g.,
increased insulin resistance and dysregulation of glucose
metabolism).
Emerging evidence that dietary restriction can forestall the
development of AD and PD is consistent with a major "metabolic"
component to these disorders, and provides optimism that these devastating brain
disorders of aging may be largely preventable.
Ann N Y Acad Sci
1999;893:154-75
Mattson MP, Pedersen WA, Duan W, Culmsee C, Camandola
S
Laboratory of Neurosciences, National Institute on Aging, Baltimore,
Maryland 21224, USA.
[log in to unmask]PMID:
10672236, UI: 20136167
<snip>