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Dear Carol and Doug, My experience w/comtan is pretty positive, although it represents a fairly dramatic change. I've recently taken (6 weeks ago) my neuro's advice to swap it for Tasmar, in order to have the benefits of the latter as a compt inhibitor w/out the potential side effects. But, that was a dosage of 100 mg. Tasmar thrice daily, now substituting for it 5, 200 mg. comtans. The comtan producers say it must be taken w/each sinemet, and indeed I've found that essential. Initially we tried only 3/day, but I was having significant off periods, seemingly related to the two sinemets/day unaccompanied by either Tasmar or comtan, so we went up to the 5 comtans to match the 5 sinemet dosages. The result has been much more even, even moreso than previously on the 3 Tasmar. I'll be interested to hear about Doug's experiences w/comtan. John Bachman 57/4.5