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I have had chronic leg cramps for about 4 years. Leg cramps are usually a sign that you need more Sinemet. That usually helps me, but when it doesn't I have Quinine Sulphate 260mg tablets my neurologist prescribed. 1/2 tab will generally solve the problem, even if only temporarily. I also have a heavy duty cordless electric massager with built-in heat that helps when the cramps get bad. Hope this will prove of some help. Bill Butch Jacksonville, Florida