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Karl, et al.... It's my understanding (and correct me if I'm wrong) that virtually all the anti-depressant-type drugs, whether old or new, require a few weeks to really kick in and do whatever it is they're s'posed to do for ya. Certainly that's true of Zoloft... I suggest - whichever drug of this type you decide to take - give the med enough time to do it's thing before you consign it to the "didn't work" pile. Hang in there, m'friend - ain't no overnite wonders (YET) with PD meds. Barb Mallut [log in to unmask] -----Original Message----- From: Karl Taeuber <[log in to unmask]> To: [log in to unmask] <[log in to unmask]> Date: Thursday, March 09, 2000 7:42 PM Subject: Antidepressants >For mild depression in a person with Parkinson's, is there any reason to >prefer an older tricyclic antidepressant like amitriptyline or imipramine >over the newer SSRI antidepressants like Prozac, Zoloft, or Paxil? > >I tried Zoloft for a week and it seemed to make the Parkinson's symptoms >worse, so I discontnued it and now just tough it out.