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Julius, I have taken Sinemet Cr 50/200 with alternating doses of Tasmar 200mg and Mirapex 1mg both 3 times a day for a total of 6 doses. 1every 3 hours with nothing overnight. I have very little off time and 0 dyskinesias. The dyskinesias were eliminated by Pallidotomy x2. Mirapex seems to have the stronger effect of the two. For a three week period I tried comtan and eliminated the other two meds. I crashed big time. Comtan seemed to have no positive effects for me. Using mirapex in conjunction Tasmar eliminated all Diarrhea. If anything, I tend to be a little constipated. Greg Leeman ----- Original Message ----- From: Julius Margolis <[log in to unmask]> To: <[log in to unmask]> Sent: Wednesday, March 08, 2000 11:10 PM Subject: Tasmar, Comtan, and Diarrhea > My wife, Doris 77/7, Took Tasmar in 98, developed severe diarrhea, dropped > Tasmar and began Comtan when it became available. > Tasmar was a blessing. Dyskinesia and off phenomena were sharply reduced. > We cut back on Sinemet and she had a significant increase in energy. She > took three doses of 100mg for one month and when she increased he dosage to > 200 (3x) she had a major attack of diarrhea. We stopped Tasmar. When things > were stabilized we tried Tasmar again with 100 (3x, but diarrhea broke out > again and we abandoned Tasmar. > Comtan has been much less effective. At first we thought there was some > improvement, but now we believe that its advantage is slight. > Has anyone else had our experience with Tasmar and then was able to return > to it, with a very gradual titration. I think we would be willing to go > back to Tasmar if we felt that there was a dosage regimen which would > eliminate the diarrhea. > She had similar experience with Permax. She had started it and developed > severe nausea. We abandoned it and then a new neuro started us again with a > minimum dosage and then a very slow buildup. Permax was an excellent addition. > Unfortunately, there is far too little research on dosage problems > To repeat: Has anyone experienced a dosage regimen of Tasmar which had > avoided diarrhea? >