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I just came across these interesting new articles in the AMA's Archives of Neurology: "Is Levodopa toxic?" http://archneur.ama-assn.org/issues/current/full/ncn8639.html "Levodopa toxicity in Parkinson Disease: Reality or Myth?" http://archneur.ama-assn.org/issues/current/full/ncn8638.html "Levodopa toxicity" http://archneur.ama-assn.org/issues/current/full/ncn8640.html Despite the titles, these articles are encouraging. Apparently, research does *not* support the theory that levodopa hastens disease progression or cell death. On the contrary, levodopa extends life and decreases disability. The real "toxicity" concern, the authors say, is whether/how levodopa really is related to motor fluctuations and dyskinesia.