Someone said <I think that the authors of the articles do *not* believe that levodopa makes Parkinson's worse, but they disagree on whether levodopa likely causes problems like motor fluctuations. > I find that in my particular case, after taking Sinemet (levodopa) my PD symptoms (bradykinesia, akinesia, other motor skill deficits, loss of sense of smell) worsen substantially almost immediately following taking of Sinemet [regular, not CR] and then a few minutes later symptoms improve to a point I am practically symptom free for a while. Then.... the cycle repeats. The "contrary reaction" has been reported in the literature by others. I would not consider this a toxic reaction. Will Johnnston A.P.D.A. DelMarVA Chapter Pres. 4049 Oakland School Road Salisbury MD 21804 USA 410-543-0110