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-----Oorspronkelijk bericht-----
Van: Sid Levin <[log in to unmask]>
Aan: [log in to unmask] <[log in to unmask]>
Datum: woensdag 22 maart 2000 0:54
Onderwerp: Any info on TNF Alpha ?


Can anyone give me info on TNF Alpha.
Apparently it's an Antibody Receptor Blocker.
The've asked me to go intoa double-blind study with it and I can't seemto
find much about it.
I'd appreciate any and all info you have or can refer me to.
[log in to unmask]


Some sites and some PubMed abstracts:

http://www.ncl.ac.uk/child-health/guides/TNF.htm

http://www.uwcm.ac.uk/uwcm/mg/search/120441.html

http://www.rndsystems.com/cyt_cat/ihc/ictnfa.html

http://www.adis.com/files/biodrugs/683554.html

http://www.biologists.com/JCS/112/01/jcs1563.html

http://members.tripod.com/~ThJuland/tnf-ms.html

PUBMED:

Hasegawa Y, Inagaki T, Sawada M, Suzumura A.
Impaired cytokine production by peripheral blood mononuclear cells and
monocytes/macrophages in Parkinson's disease.
Acta Neurol Scand. 2000 Mar;101(3):159-64.
PMID: 10705937

Sumitran S, Anderson P, Widner H, Holgersson J.
Porcine embryonic brain cell cytotoxicity mediated by human natural killer
cells.
Cell Transplant. 1999 Nov-Dec;8(6):601-10.
PMID: 10701489

Dobbs RJ, Charlett A, Purkiss AG, Dobbs SM, Weller C, Peterson DW.
Association of circulating TNF-alpha and IL-6 with ageing and parkinsonism.
Acta Neurol Scand. 1999 Jul;100(1):34-41.
PMID: 10416510

Mogi M, Togari A, Tanaka K, Ogawa N, Ichinose H, Nagatsu T.
Increase in level of tumor necrosis factor (TNF)-alpha in
6-hydroxydopamine-lesioned striatum in rats without influence of systemic
L-DOPA on the TNF-alpha induction.
Neurosci Lett. 1999 Jun 18;268(2):101-4.
PMID: 10400088

Bessler H, Djaldetti R, Salman H, Bergman M, Djaldetti M.
IL-1 beta, IL-2, IL-6 and TNF-alpha production by peripheral blood
mononuclear cells from patients with Parkinson's disease.
Biomed Pharmacother. 1999 Apr;53(3):141-5.
PMID: 10349502

Hunot S, Dugas N, Faucheux B, Hartmann A, Tardieu M, Debre P, Agid Y, Dugas
B, Hirsch EC.
FcepsilonRII/CD23 is expressed in Parkinson's disease and induces, in vitro,
production of nitric oxide and tumor necrosis factor-alpha in glial cells.
J Neurosci. 1999 May 1;19(9):3440-7.
PMID: 10212304

Le WD, Rowe DB, Jankovic J, Xie W, Appel SH.
Effects of cerebrospinal fluid from patients with Parkinson disease on
dopaminergic cells.
Arch Neurol. 1999 Feb;56(2):194-200.
PMID: 10025424

Ruberg M, France-Lanord V, Brugg B, Lambeng N, Michel PP, Anglade P, Hunot
S, Damier P, Faucheux B, Hirsch E, Agid Y.
[Neuronal death caused by apoptosis in Parkinson disease].
Rev Neurol (Paris). 1997 Sep;153(8-9):499-508. Review. French.
PMID: 9683999

Muller T, Kuhn W, Kruger R, Przuntek H.
Selegiline as immunostimulant--a novel mechanism of action?
J Neural Transm Suppl. 1998;52:321-8.
PMID: 9564633

Bjugstad KB, Flitter WD, Garland WA, Su GC, Arendash GW.
Preventive actions of a synthetic antioxidant in a novel animal model of
AIDS dementia.
Brain Res. 1998 Jun 8;795(1-2):349-57.
PMID: 9622673

Aloe L, Fiore M.
TNF-alpha expressed in the brain of transgenic mice lowers central tyroxine
hydroxylase immunoreactivity and alters grooming behavior.
Neurosci Lett. 1997 Nov 28;238(1-2):65-8.
PMID: 9464656

Bongioanni P, Castagna M, Maltinti S, Boccardi B, Dadone F.
T-lymphocyte tumor necrosis factor-alpha receptor binding in patients with
Parkinson's disease.
J Neurol Sci. 1997 Jul;149(1):41-5.
PMID: 9168164

Ruberg M, Brugg B, Prigent A, Hirsch E, Brice A, Agid Y.
Is differential regulation of mitochondrial transcripts in Parkinson's
disease related to apoptosis?
J Neurochem. 1997 May;68(5):2098-110.
PMID: 9109538

Shen Y, Li R, Shiosaki K.
Inhibition of p75 tumor necrosis factor receptor by antisense
oligonucleotides increases hypoxic injury and beta-amyloid toxicity in human
neuronal cell line.
J Biol Chem. 1997 Feb 7;272(6):3550-3.
PMID: 9013604

Bieganowska K, Czonkowska A, Korlak J.
Pargyline pretreatment prevents immunological changes induced by MPTP in
mice.
Immunopharmacology. 1996 Nov;35(2):149-54.
PMID: 8956978

Pereira HA, Kumar P, Grammas P.
Expression of CAP37, a novel inflammatory mediator, in Alzheimer's disease.
Neurobiol Aging. 1996 Sep-Oct;17(5):753-9.
PMID: 8892348

Tomimoto H, Akiguchi I, Wakita H, Kinoshita A, Ikemoto A, Nakamura S, Kimura
J.
Glial expression of cytokines in the brains of cerebrovascular disease
patients.
Acta Neuropathol (Berl). 1996 Sep;92(3):281-7.
PMID: 8870830

Mogi M, Harada M, Narabayashi H, Inagaki H, Minami M, Nagatsu T.
Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth
factor-alpha levels are elevated in ventricular cerebrospinal fluid in
juvenile parkinsonism and Parkinson's disease.
Neurosci Lett. 1996 Jun 14;211(1):13-6.
PMID: 8809836

Agid Y.
[Aging, disease and nerve cell death].
Bull Acad Natl Med. 1995 Jun;179(6):1193-203; discussion 1203-7. French.
PMID: 8542348

Mogi M, Harada M, Kondo T, Riederer P, Nagatsu T.
Brain beta 2-microglobulin levels are elevated in the striatum in
Parkinson's disease.
J Neural Transm Park Dis Dement Sect. 1995;9(1):87-92.
PMID: 7605592

Boka G, Anglade P, Wallach D, Javoy-Agid F, Agid Y, Hirsch EC.
Immunocytochemical analysis of tumor necrosis factor and its receptors in
Parkinson's disease.
Neurosci Lett. 1994 May 19;172(1-2):151-4.
PMID: 8084523

Lipton SA.
HIV-related neuronal injury. Potential therapeutic intervention with calcium
channel antagonists and NMDA antagonists.
Mol Neurobiol. 1994 Apr-Jun;8(2-3):181-96. Review.
PMID: 7999315

Davies KN, King D, Davies H.
A study of the nutritional status of elderly patients with Parkinson's
disease.
Age Ageing. 1994 Mar;23(2):142-5.
PMID: 8023723

Mogi M, Harada M, Riederer P, Narabayashi H, Fujita K, Nagatsu T.
Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in
the cerebrospinal fluid from parkinsonian patients.
Neurosci Lett. 1994 Jan 3;165(1-2):208-10.
PMID: 8015728

Selmaj K, Raine CS, Cannella B, Brosnan CF.
Identification of lymphotoxin and tumor necrosis factor in multiple
sclerosis lesions.
J Clin Invest. 1991 Mar;87(3):949-54.
PMID: 1999503