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There is a recent multifaceted study of reviews on monotherapy of agonists or combined with Sinemet for all three drugs: pergolide (Brand: Permax), pramipexole Brand: Mirapex) & ropinerole (Requip). with comparative usage and efficacy. > SOURCE Medical Clinics of North America Volume 83 * Number 2 * March 1999 Copyright - 1999 W. B. Saunders Company After eighty heavy pages the author sums it up as follows: There is no perfect med. The Doc must work with the patient and test the patients reactions. If after an eighty page review of all the other tech articles, he comes up with a generality of that kind, we PWP's cannot resolve the issue either. It still boils down to trial and error. And error should be spelled with all caps and bold. Sid Levin PS I'm on Mirapex alone 1.5 mg 3xDay and titrating up to 2.0 3xDay. Seems to help my tremor. Sinemet did not, but when I get Mirapex to the desired level, I'll slowly add some Sinemet. There are no simple solutions to complex questions!