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Jerry: I take 3mg requip 3x/day and Sinemet CR 25/100 in the AM. The requip replaced other doses of Sinemet and I find I am more cavalier with the requip than I ever was with Sinemet. I take (and took) my Sinemet at least one hour before eating an extremely low protein meal. I take my morning requip with the Sinemet because it's convenient. I take my noon and dinner Requip sometimes before, sometimes during and sometimes after the meal with seemingly the same results. Fortunately, it doesn't make me nautious (sp?) so the timing seems to be immaterial. I also don't concern myself much with the protein except at breakfast, an hour after my only Sinemet of the day. Paul H. Lauer