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Jim, I tried first Mirapex(sleepy all the time) and then PERMAX 0r Pergolide(acid reflux and not enough relief from rigidity and stiffness). Stastistic showed 48 percent of test group improved w/Pergolide alone and some 30+ precent had slight improvement. It's worth a try and maybse you'll be in the 48percent!!! Used sinemetCR alone for 6 months successfully....now adding REQUIP. Nothing like our human lab rat role to try and find the "perfect meds". Jeanette Fuhr 49/47/44? ---------- From: Jim Wiles <[log in to unmask]> To: [log in to unmask] Subject: Pergolide without Levodopa Date: Wednesday, March 22, 2000 1:41 PM Hi, has any PWP tried using an agonist such as Pergolide without Levodopa. I started the increasing dosage from 0 to 0.75 mgrams as prescribed and have subsequently increased the dosage by 0.25 mgrams per week over the last month. I have now reached a total dose of 1.75 mgrams per day and although I am getting many of the side affects nausea, dizziness, etc the benefits are missing. I wonder if I am increasing the dose too fast/slow or is the level still too low to give any benefits? Has anybody successfully used agonists without Levodopa ? Cheers Jim 59/49/48