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Subject: [pdnews] THC346 Stops Progression of PD in monkeys
Date: Sat, 25 Mar 2000 23:21:41 -0500
From: Judith Richards <[log in to unmask]>
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To: "Parkinson's Disease News" <[log in to unmask]>
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Source: University Medical Center St. Radboud, Nijmegen, The
Netherlands.
22 March 2000
THC 346 stops symptoms of PD in monkeys
Two neurobiologists from Nijmegen (the Netherlands) have found the
compound
THC 346 to stop the progression of PD in monkeys completely. Within 3
months
a trial will start with PWP. The medicine might also have a positive
effect
upon ALS and Alzheimers.
One of the researchers, Prof. dr. A. Cools of the University Medical
Center
St. Radboud, said the discovery to be every researchers dream. He and
his
collegue Andringa could not believe it when they saw the effect of THC
346
in tests with rhesus monkeys. Worldwide researchers never before
succeeded
in actually stopping the progression of PD, Cools said.
THC346 stops the apoptose of the neurons completely. This was found in
studies with rats and rhesus monkeys, injected with a compound that
induced
PD. The sick monkeys that then had an injection of THC 346, showed no
more
progression in motoric or behavioral problems. Cools is convinced that
these
effects will also be found in the study with humans. THC 346 can be
taken
orally (pill) by PWP.
The neurobiologist stressed that the compound does not cure PD. Symptoms
that already appeared, will stay. But if PWP have their first symptoms,
these symptoms are still minimal. Untill now therapy was often delayed
because of severe side-effects of the available medication. THC346 makes
it
possible to stop the progression in an early phase at a level that
people
still can function quite normal.
The researchers are still trying to find out how much and how long THC
346
has to be taken to stop the apoptosis of the neurons definitively. Cools
hopes one period of treatment will be sufficient in the early phase of
PD.
In advanced PD it will probably take several treatment periods to stop
the
progression.
THC 346 is tested upon healthy persons in Switzerland and found to be
save.
Cools expects worldwide studies of THC 346 use for ALS and Huntington's
to
start within the year. These diseases are also due to apoptosis. If the
human trials with PWP have the same effects as the studies with monkeys,
the
medication is expected to be available to the public in 3-5 years.
--
Judith Richards, London, Ontario, Canada
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Today’s Research...
Tomorrow’s Cure
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