Intermembrane Space Mitochondria: http://www.lbl.gov/~jwl/
Subunit 8 The Reiske protein is critical to
the oxidation of ubiquinol.
Cytochrome c1 (Subunit 4) The Reiske cluster is [2Fe-2S]
HEME c1 The Reiske iron is given to
ferrochelatase who gives it to make porphyrin and heme.
ISP (Subunit 5) Manganese Toxicity Parkinsons
inhibits the iron from reaching ferrochelatase.
[2Fe-2S] Cluster MPTP inhibits Porphyrin.
Tellurium-Ferric clusters cannot be used by ferrochelatase.
PMID 10591529 Role of the Reiske iron-sulfur protein midpoint potential in
the protonmotove Q-cycle mechanism of the cytrochrome bc1 complex.(CYT c1 &
CYT b1)
PMID 3931555 Reconstitution of heme-synthesizing activity from ferric ion
and porphyrins, the effect of lead on the activity.
Taketani S, Tanaka A, Tokinga R Arch Biochem Biophys 1985 Oct; 242(1):
291-6
These results indicate that the NADPH oxidizing system reduces ferric ion
to ferrous ion. This ferrous ion is then utilized for heme synthesis by
ferrochelatase.
PMID 229912 Preparation and partial characterization of iron-sulphur,
iron-selenium, and iron-tellurium complexes of bovine serum albumin.
Arakawa S, Kimura T Biochem Biophys Acta 1979 Oct 24; 580(2): 382-91
These results imply that both selenium and tellurium can be incorporated
into the 2Fe-2S protein molecule as the respective labile components.
Tellurium is a sulphur-like element that can take the place of sulphur and
binds metals.
http://galleries.com/minerals/sulfates/class.htm
PMID 10506125 Role of cytochorme c as a stimulator of alpha-synuclein
aggregation in Lewy body disease.
Hashimoto M, Takeda A, Hsu LJ, Takenouchi T, Masliah E Journal of
Biological Chemistry Oct 1999 8;274(41):28849-52
The potential role of the heme protein cytochrome c and alpha synuclein
aggregation. Taken together, these results suggest that cytochrome c, a
well known electron transfer, and mediator of apopotic cell death may be
involved in the oxidative stress-induced aggregation of alpha-synuclein in
Parkinsons disease and related disorders.
Flies May Hold Key to New Parkinsons Treatment - Reuters March 23, 2000
Feany created transgenic fruitflies by inserting a human gene called
alpha-synuclein which is involved in Parkinsons Disease.
The flies showed many of the physical traits of patients suffering with
Parkinsons Disease.
Porphyrin Functionalization
http://www-chem.ucdavis.edu/groups/smith/research/porph_funct/WebPF1.html
The cation radicals of metalloporphyrins react with various nucleophiles
(pyridines).
MPTP or N-Methyl-4-phenyl-1,2,3,6-tetropyridine
Street-Drug Contaminant Causing Parkinsonism by the National Institute on
Drug Abuse and the National Institute of Mental Health.
PMID 10385886 Manganese Neurotoxicity: a review of clinical features,
imaging and pathology by Pal PK, Sammi A, Calne DB
Neurotoxicology 1999 April-Jun, 20(2-3) :227-38 Manganese Intoxication can
result in a syndrome of Parkinsonin, and dystonia.
PMID 10383398 Mechanism of iron transport to the site of heme synthesis
inside yeast mitochondria. Lange H, Kispal G, Lill R
J Biological Chem 1999 Jul2, 274 (27); 18989-96 Iron in mitochondria is
required for the biosyntesis of heme and various iron-sulphur proteins.
Iron cannot be preloaded in the mitochondrial matrix but rather has to be
transported across the inner membrane simultaneously with the synthesis of
heme, suggesting that ferrochelatase receives iron directlyt from the inner
membrane. Transport of iron is inhibited by manganese.
Sure looks like Tellurium which is used as a catalyst in cracking petroleum
to make jet fuel, diesel fuel and gasoline causes Parkinsons Disease.
Sorry for all the Authors and Publications. My computer won't let me into
Pub Med today.
Tellurium would become part of the Reiske Cluster that reacts with
cytochrome c that aggretates alpha synuclein into lewy bodies found in
Parkinsons Disease.
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