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FWIW, 1 or 2 25/100 tablets is too little carbidopa to make the levodopa last long enough to do much. the doctors can provide Lodosyn free from Merck or Dupont, but they seldom do this. it is carbidopa to give 75 mg. per day. It is best to take small doses of levodopa IF they seem sufficient to the patient. taken as half 25/100 tablets six times at 2.25 hour intervals throughout the day; 3 tablets of 25/100 is usually sufficient for a while - and, it gives little likelihood of dyskinesia. few need any at night for 10 years. <[log in to unmask]> writes: > For the last years I have had a Mild to Moderate PD. I have been > getting by on > 25/100 Sinemet 1 a day, 1 MG Mirapex 3 X day and Eldepryl 2 X day. > I had heart bypass surgery on Nov 1998. Beginning on March 1999, I > started to > feel a heavyness in my legs, but I did not pay much attention to > that, walking > took care of it. > Last November, I experienced what I called a Frozen state where I > almost keeled over. > I talked to my Neurologist who said that I was on a very low dosage > of Sinemet, so he > upped it to 25/100 twice a day. > That has not helped much, I notice that any kind of physical > activity gives me the > heavy legs. Whereas before walking helped, now it aggravates it. -- Ron Vetter 1936, '84 PD dz mailto:[log in to unmask] http://www.ridgecrest.ca.us/~rfvetter