The label CR indicates a controlled release medication. One method to achieve the controlled release is to coat the tablet with a special coating of a substance that dissolves slowly, but the tablet is broken, the slow release effect is destroyed and that broken tablet works just like any other NON CR medication. Michel Cari Barrett wrote: > i'm always amazed at the emails i read about how much or little Sinemet is > taken - but i rarely see anything about 1/2s or 1/4s of the tablets taken - > after 16+ years, my dad is only taking: > > 6A 1/4 Sinemet 25-100 * > * CRUSHED IN SPOON for quicker absorption - aides > in faster mobility > 1/2 CR 50-200