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I hear that the fastest way to get the Sinemet to the brain is by grinding it and dissolving it in a solution of Vit. C (I would use orange juice) to increase its stability for the day. Our neuro insists on drinking a full glass of water with pill. I've read that some people make enough of this mixture to last the day. Good luck Michel Cari Barrett wrote: > We DID try chewing a portion of a CR, but it didn't hit fast enough and when > it finally did, in conjunction with the next doses - he was so dyskenetic it > was awful - > > The 25-100 crushed with his morning meds has made a huge difference (for the > most part!) but as we all know - every day is a surprise!!!!