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Hi Dear Folks, I was a subscriber before but became overwhelmed with life :-). As caregiver to my mother PWP 80/15, I'm racing to find information about anti-anxiety/anti-depression drugs that are considered better for PWP. Her present doctors have just prescribed Zoloft, and I'm wondering whether there are other drugs that are generally considered more appropriate for PWP. The Zoloft is for my mother's anxiety, including panic attacks. Until last week, my mother had been taking Zyprexa 5mg at night for about 8 months, and it seemed give comfort emotionally and physically. The doctors have slowly cut out the Zyprexa, saying the fewer drugs the better. They also said long term effects of Zyprexa may be a problem some day. She's taken no Zyprexa for a week now, and her rigidity during off times is more intense and she feels less capable in general. She's much more anxious. Her anxiety could be other factors, e.g., one dear nurse's aide is leaving, but I'm not certain. In any case, I keep trying to print info from the Parkinsn Drug Database and from other sections of John Cottingham's site, but my Netscape keeps crashing. My main question is: What are the drugs that most people think of when treating anxiety and depression in PWP? If I knew the drug names or could find citations, I'd be able to discuss the issues better with the doctors who have just now prescribed Zoloft. They will consult with a neurologist if needed, but it may not be someone with strong PD experience. (My mother has peripheral neuropathy in addition to PD, and she is very stressed by the prospect of leaving the house). So we're relying on very caring general doctors who have established a house call practice out of a prestigious local hospital.) Many thanks for any pointers about drug names and Parkinsn community wisdom on anti-anxiety drugs. -- Lynne [log in to unmask]