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did the amount of sinemet get reduced when the comtan was started? if not, it should be. if the PD symptom that came back is dyskinesia (unwanted movements such as jerking or tremor or squirming) that occurs about 45 minutes after taking sinemet, this is because the comtan preserves the levodopa longer in the bloodstream. Too high a peak in concentration is the most frequent cause of dyskinesia. best to all on Dr Parkinsons birthdate anniversary, ron >My wife recently started taking Comtan. Some of the PD symptoms have come >back. What effect can too much Sinemet cause? I understand the proper >balance is vital; too little not good; too much not good. Any comments and >help on this matter much appreciated. > >Paul >[log in to unmask] -- Ron Vetter 1936, '84 PD dz mailto:[log in to unmask] http://www.ridgecrest.ca.us/~rfvetter