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It is important to realize that "neuro-active" drugs act differently in different people with or without interactions between these drugs and other medications. No individual patient's experience will be a reliable indication of how those drugs will act in anyone else. This situation is particularly true with the Family of drugs called "SSRI". Zoloft is a member of this family (as is Prozac etc) and the family is expanding. My own experience has been wonderful with Zoloft and poor with Prozac. Ken Janis