Howsabout this?
1 : Neurology 1999 Jan 1;52(1):115-9
Smoking and Parkinson's disease: a dose-response
relationship.
Gorell JM, Rybicki BA, Johnson CC, Peterson EL
Department of Neurology, Henry Ford Health
System, National Institute of
Environmental Health Sciences Center in Molecular
and Cellular Toxicology with Human Applications, Wayne State University,
Detroit, MI, USA.
OBJECTIVE: To determine whether an inverse dose-response relationship
exists between cigarette smoking and PD among ever-smokers and ex-smokers.
METHODS: Smoking and alcohol consumption were analyzed in 144 PD patients
and 464 control subjects, who were frequency matched for sex, race, and
age (+/-5 years), in a population-based case-control study of men and
women > or =50 years old in the Henry Ford Health System. RESULTS: With
never-smokers as the reference category, there was an inverse association
between current light smokers (>0 to 30 pack-years) and PD patients (odds
ratio [OR], 0.59; 95% CI, 0.23 to 1.53), and a stronger inverse
association of PD with current heavy smokers (>30 pack-years; OR, 0.08;
95% CI, 0.01 to 0.62). When former >30-pack-year smokers were stratified
by the interval since quitting, there was an inverse association between
those who stopped >20 years ago and PD (OR, 0.86; 95% CI, 0.42 to 1.75),
and a greater inverse relationship with those who stopped 1 to 20 years
ago (OR, 0.37; 95% CI, 0.19 to 0.72). Alcohol consumption had no
independent, significant association with PD, but heavy drinking (>10
drink-years) had a greater effect than light-moderate drinking in reducing
but not eliminating the inverse association between smoking and PD.
CONCLUSIONS: The inverse dose-response relationship between PD and smoking
and its cessation is unlikely to be due to bias or confounding, as
discussed, providing indirect evidence that smoking is biologically
protective.
Comments:
Comment in: Neurology 1999 Sep 22;53(5):1158
PMID: 9921857, UI: 99118830
Judy George wrote:
> my daughter saw the article on nicotine in
> the /a Journal of Neuroscience
> we have no idea where and i guess this isnt helpful unles someone knows
> about that journal
> is it american,canadian.......... whatever
> regards judy
> ______________________________________________________
> Get Your Private, Free Email at http://www.hotmail.com
I just sent this off to Charlie.
I think someone isolated the active component...and it wasn't nicotine.
I went looking for the abstract and didn't find it.
Instead, I found 195 articles by searching for -- parkinson smoking
at PubMed.
I'm going to send you some of the abstracts--oh heck, just go look for yourself
at:
http://www.ncbi.nlm.nih.gov/PubMed/
I've got to get some sleep.
Lot's of luck. :-)
and don't start smoking quite yet.
--
..........................................................................
Ray Strand
mailto:[log in to unmask]
48/47/45?
..........................................................................
...on the edge of the prairie abyss ......................
