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the change to 50/200 CR is ignoring all the hidden problems of CR: it is overdosing - also has erratic peaks it does not work well for elderly it is promoted by the drug company because it is more profitable it's efficacy is about 77% is very slow usually in getting effective should not be used when 25/100CR or half or 1/4 of a 50/200 might work the increasing rigidity may be advancement of symptom or it may be random and change throughout the day the sinemet CR is not likely to change the tremoring or the rigidity any differently the dosage time maximum is about 2.5 hours fro regular meds and 4 hours for the CR (as whole, half, or quarter - crumbled is likely to give a very strong unpleasant response) most of his day your father is not having sufficient levodopa in his bloodstream with one upon awaking and the second before supper tell the doctor to learn something from the real data and experience of many by going back to the 25/100 and taking halves of that at 2 to 2.5 hour intervals from arising until two or three hours before retiring. that should give benefit all day long unless he eats a large meal or one with too much protein. The best advice is twice as often with half as much until you get to near-level blood concentration of levodopa in bloodstream there is some data here: http://www.ridgecrest.ca.us/~rfvetter/levodopa.pdf you or the doctor will need adobe acrobat reader to open the .PDF file >I would love to ask this question for my 72yr Father; and hopefully I have >all the pertinent info. My Dad has been on Sinemet for 2 years; the 25/100 >dose. It seemed to work well with him. His last visit to the >neurologist; the doctor informed him that he is getting quite stiff in his >right arm (the right arm is the arm that shakes quite a bit); and therefore >wanted to change him to 50/200 CR Sinemet. I believe this is a >time-release Sinemet? Well, the last 2 days my Dad has been following the >new medicine schedule (5am and 4pm); and when he is sitting his right arm is >shaking much more than ever. Also, he hasn't slept much at all since >changing the dosage. According to the info that came with the drug; it may >take several weeks to adjust to this medicine; etc. > >Any insight to this would be greatly appreciated, as always, > >Wanda. >________________________________________________________________________ >Get Your Private, Free E-mail from MSN Hotmail at http://www.hotmail.com -- Ron Vetter 1936, '84 PD dz mailto:[log in to unmask] http://www.ridgecrest.ca.us/~rfvetter