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Ivan, I have been using the generics for years without any problem. I would think that the time of onset might possibly be affected slightly since it physically is a different preparation. But it should not be a significant difference. I think that many people on the list have been taking the generic wtithout problem- and the differences my be more from the fact that you are looking for them rather than any direct physical difference. It is often frightening to switch from one preparation to another and I think that the drug companies count on that to keep the prices of their brand name drugs much higher than their generics even when they are often made by the same companies- at the same plant and just distributed under a different name. Good luck . BTW If you have been taking generics before and don't feel that you are getting the same generics ask your Pharmacist whether he has swithched generics on you. Charlie ----- Original Message ----- From: "Ivan M Suzman" <[log in to unmask]> To: <[log in to unmask]> Sent: Saturday, April 22, 2000 8:54 AM Subject: Trouble with "generic" carbidopa/levodopa 25/100 > A medical question: > > My government insurance (Medicaid) > requires generic substitutes > for "brand names," and I have no choice, > unless I pay out-of-pocket. > > The most recent refill of my "generic" > carbidopa/l-dopa 25/100 prescription > was composed of pills that were drier, > and slightly paler than usual-like a > faded lemon pastel color, but strangely > chalky. > > They have not worked as quickly, > nor have they lasted as long. I do not > know whether it is PD or the pills or > something else that made them noticeably > different. > > The pharmacist just told me that > the generic brand is actually an Israeli drug company's > product. The company is Teva. > > Does anyone have comments or > suggestions on what you might do next? > > Ivan > 50/39/36