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Thanks Hans,I am thinking thaat your last statement is going to apply to me. In response to other replies, I had taken no other med's today. I just don't see how I can take another dose of sinemet as bad as I am having tremors now. I am afraid that I am not going to get any relief from drugs. It is not 4 1/2 hours and the tremor is still worse than it every was before taking the sinemet. Lanier Maddux _____________________________________________ NetZero - Defenders of the Free World Click here for FREE Internet Access and Email http://www.netzero.net/download/index.html