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It is difficult to understamnd why you had such a reaction to such a small dose of Sinemet. Under normal circumstances, unless you take enough Carbidopa (the 25 of 25/100), most of the levodopa will be metabolized before it even gets into the brain - this may cause side effects. Some PWP taking small doses of carbidopa/levodopa find that they have fewer side effects when they actually increase the dose somewhat to make sure they are taking enough carbidopa - usually at least 75 mg per day. An alternative is to use Lodosyn (pure carbidopa) supplement which is now available by prescription also. Jorge Romero, MD ----- Original Message ----- From: plmaddux <[log in to unmask]> To: <[log in to unmask]> Sent: Tuesday, April 25, 2000 6:26 PM Subject: Bad reaction to sinemet, info please > I just took my first dose of sinemet and am having a bad reaction, I have > tremor as only symptom, took 1/2 of 25/100 witha light meal at 5pm, two > hours later my tremor in 4 times as violent as it has ever been, just talked > to doctor, he was no help, just said that sometimes sinemet does not help > tremor. what is going on here, i never heard of sinemet making sympoms worse > rather than better. > > Lanier Maddux 64,4 > > _____________________________________________ > NetZero - Defenders of the Free World > Click here for FREE Internet Access and Email > http://www.netzero.net/download/index.html >