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To Ron, Camilla and DR Romero all who replied to my mail. I took the 1/2 25/100 sinemet with a light meal, chicken noodle soup and some rice and beans. And water only to drink. No other drugs had been taken that day. My tremor is now 4 1/2 years in progress. Not disabling but very annoying and tiresome. Some muscle ache late in the day, is helped with a ibuprofen with bedtime snack. Also an occasional Ativan for tempory relief for a couple of hours. Otherwise my health is good, and I am sleeping wwell although that is tenuous at times. When I developed the severely increased tremors I called my doctor and he would only say that "sinemet is a difficult drug to take" He also said I may have to go back to Artane, but I had a bad reaction to that drug also. So I am rethinking my options for now. I hope I have answered all the questions. Thank you all again for the responses and information. Lanier Maddux _____________________________________________ NetZero - Defenders of the Free World Click here for FREE Internet Access and Email http://www.netzero.net/download/index.html