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-----Oorspronkelijk bericht----- Van: W M <[log in to unmask]> Aan: [log in to unmask] <[log in to unmask]> Datum: donderdag 27 april 2000 16:08 Onderwerp: Sinemet dosage >> the doctor informed him that he is getting quite stiff in his right arm (the right arm is the arm that shakes quite a bit); and therefore wanted to change him to 50/200 CR Sinemet. << >> I believe this is a time-release Sinemet? << Yes. >> Well, the last 2 days my Dad has been following the new medicine schedule (5am and 4pm); and when he is sitting his right arm is shaking much more than ever. << See my reply to Lanier in one of the last days: the higher dose can give relaxation of stiff muscles which can give an (in most cases temporary) increase of the tremors. These tremors were first suppressed by the stiff muscles. >> Also, he hasn't slept much at all since changing the dosage. << Higher doses always can cause sleepproblems. >> According to the info that came with the drug; it may take several weeks to adjust to this medicine; etc. << To see the stabile result you need to use the higher dose 4-6 weeks. Hans.