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Besides any adjustments with time to be made, the lack of sleep will exacerbate symptoms and negate some of the beneficial effects of the medication. Good night sleep is a must to enable drugs to work efficiently. Michel W M wrote: > I would love to ask this question for my 72yr Father; and hopefully I have > all the pertinent info. My Dad has been on Sinemet for 2 years; the 25/100 > dose. It seemed to work well with him. His last visit to the > neurologist; the doctor informed him that he is getting quite stiff in his > right arm (the right arm is the arm that shakes quite a bit); and therefore > wanted to change him to 50/200 CR Sinemet. I believe this is a > time-release Sinemet? Well, the last 2 days my Dad has been following the > new medicine schedule (5am and 4pm); and when he is sitting his right arm is > shaking much more than ever. Also, he hasn't slept much at all since > changing the dosage. According to the info that came with the drug; it may > take several weeks to adjust to this medicine; etc.