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******************************************************** Hi Audrey and All. I responded privately to Audrey's request for info but have amalgamated the search results here into one response. Does anyone have anything to add? ------- Forwarded message follows ------- On 23 Apr 2000, at 11:05, Audrey wrote: > Hi Murray, > I am a Parkinson list member, and it seems that you are very good > at finding things on the internet. You must enjoy it! I have learned so > much from the list and believe that my husband died of CBGD just two > years after being diagnosed with Parkinson's. Just three and one-half > months as Parkinsons Plus. CBGD is Corticobasal Ganglionic Degeneration. > I also believe that he may have also had PSP. > I have joined the cbgd support on line, but it is so rare, there "seems" to > be > no organised information on it and it was a very lonely stuggle to deal > with. > And still is. If you could find the time and energy to see what you can > find, > I would be eternally gratefull. You can email me [log in to unmask] or > through > the Parkinson list. I can not rest until I get some answers. Thank you for > listening. Sincerely, Audrey Nick > Hi Audrey, I hope these links help provide some answers.... I started with the US National Library of Medicine... MeSH - Medical Subject Headings - is the US National Library of Medicine's [Bethesda, MD] controlled vocabulary used to index and catalog bibliographic and other types of biomedical information material. Alphabetical List of Specific Diseases/Disorders http://www.mic.ki.se/Diseases/alphalist.html Diseases, Disorders & Related Topics http://www.mic.ki.se/Diseases/index.html Nervous System Diseases http://www.mic.ki.se/Diseases/c10.html Central Nervous System Diseases http://www.mic.ki.se/Diseases/c10.228.html Worldwide Education for Movement Disorders http://www.wemove.org/ Corticobasal Degeneration http://www.wemove.org/cbd.html Corticobasal Degeneration http://www.ninds.nih.gov/patients/Disorder/corticobasal/corticobasal.htm Corticobasal Degeneration http://www.medemall.com/general/cortdeg.htm Corticobasal Degeneration http://healthlink.mcw.edu/article/921395030.html To Obtain Suggested Resources . . . This page offers suggestions to help you obtain copies of journal articles and excerpts from medical textbook http://www.ninds.nih.gov/patients/fs-guide.htm Corticobasal Ganglionic Degeneration This is a webforum to discuss and comment on CBGD http://neuro-www.mgh.harvard.edu/forum/Cortico.Gang.Deg.Menu.html Cortical Basal Ganglionic Degeneration http://www.emedicine.com/NEURO/topic77.htm CorticoBasal Ganglionic Degeneration (CBGD) http://www.neuro.nwu.edu/meded/MOVEMENT/corticobasal.html Baylor Neurology Case of the Month Patient #17 - CorticoBasal Ganglionic Degeneration (CBGD) http://www.bcm.tmc.edu/neurol/challeng/pat17/menu.html http://www.bcm.tmc.edu/neurol/challeng/pat17/history.html http://www.bcm.tmc.edu/neurol/challeng/pat17/warning.html http://www.bcm.tmc.edu/neurol/challeng/pat17/labtest.html http://www.bcm.tmc.edu/neurol/challeng/pat17/summary.html Patient #17 - Self Test Corticobasal Ganglionic Degeneration (CBGD) http://www.bcm.tmc.edu/neurol/challeng/pat17/selftest.html Corticobasal Ganglionic Degeneration Web Forum http://132.183.145.103/forum/Cortico.Gang.Deg.Menu.html Corticobasal Ganglionic Degeneration and Progressive Supranuclear Palsy Presenting with Cognitive Decline http://brainpathology.upmc.edu/vol8/0802/82a9.htm Differential Diagnosis of Parkinson's Disease and The Parkinsonism http://www.hooked.net/~ccjm/shy-drager/mail-archive/0523.html Parkinson Plus http://dem0nmac.mgh.harvard.edu/neurowebforum/GeneralFeedbackArticles/Park insonPlus.html This response submitted by Neurologist on 9/9/95. Parkinson Plus is a term used to describe numerous disorders characterized by parkinsonian features (rigidity, slow movements, tremor) PLUS other neurological signs such as incoordination of gait, muscle wasting, or autonomic disturbances. More specific terms are sometimes used depending on the clinical features: Shy-Drager syndrome, olivo-ponto-cerebellar degeneration, striato nigral degeneration, supranuclear palsy, dentato-rubro-pallido-luysian atrophy etc. They all have in common degeneration of brain cells in various parts of the brain. Unfortunately, treatment is usually unsatisfactory. Hope this helps, Sincerely, Canadian neurologist. Patients with "Parkinson's plus" are not candidates for surgery. This is usually a patient who has PD along with 6 other neurological disorders that may so threaten the patient's life and well-being that aggressive treatment of the PD is unwarranted. A few examples of such other afflictions would include (in worsening order): Shy-Drager syndrome, Substantia Nigra Degeneration (SND), Progressive Supra-nuclear Palsy (PSP), OlivoPontoCerebellar Atrophy (OPCA) and Multisystem Atrophy. Parkinson's Plus - An Excerpt from http://alumni.engin.umich.edu/~jxm/parkguide.html Pathologic studies into the underlying cause of PD have lead to the discovery of a number of other diseases which share clinical features to PD. Approximately 80% of patients who present with the symptoms above will be found to have idiopathic PD. Approximately 8% have secondary PD (due to toxins, drugs, trauma, metabolic disorder, infection stroke, brain tumor). About 10% have Parkinson plus syndromes, a group of disorders with multiple system degeneration with neurologic involvement beyond the typical features of PD. These include eye movement problems in Progressive Supranuclear Palsy (PSP), dysautonomia (problems with blood pressure, digestion, etc...) in Shy Drager Syndrome (SDS), ataxia (poor coordination) in OlivoPontoCerebellar Atrophy (OPCA), apraxia (poor fine motor control), myoclonus (jerking) and alien hand in CorticoBasal Ganglionic Degeneration (CBGD), dementia in Alzheimer's Disease with Parkinsonism (ADP) or diffuse Lewy Body Disease (LBD), dementia with motor neuron disease with Parkinsonism Dementia Amyotrophic Lateral Sclerosis (PD-ALS). These diseases usually have less tremor, early problems with gait and poor response to Sinemet. Symptoms of Parkinsons and Parkinson's Plus http://www.pwc.k12.nf.ca/b2201/assignments/parkinsons/symptoms.html (educational, but don't believe Pallidotomy is necessarily the answer) Progressive Supranuclear Palsy http://www.neuro.nwu.edu/meded/MOVEMENT/psp2.htm Progressive Supranuclear Palsy Europe Association http://www.ion.ucl.ac.uk/PSPeur/ What is PSP? http://www.ion.ucl.ac.uk/PSPeur/web_whatis.htm Facts About Progressive Supranuclear Palsy...PSP http://www.psp.org/facts/facts.shtml Helping the Helpers - Successful Caregiving http://www.psp.org/facts/helpers.shtml Shy-Drager Syndrome or MSA http://www.ndrf.org/MSA.htm http://www.ninds.nih.gov/patients/disorder/shydrger/shydrger.htm http://neuro-www.mgh.harvard.edu/forum_2/ShyDragerF/MSAFactSheet.html Shy-Drager Syndrome Support Group 8th International Conference with the American Autonomic Society 1996 SDS conference - part 1 http://www.hooked.net/~ccjm/shy-drager/mail-archive/0524.html Parkinson's Disease http://www.neuro.nwu.edu/meded/MOVEMENT/parkinsons.html Multiple System Atrophy (MSA) http://www.neuro.nwu.edu/meded/MOVEMENT/msa.html Pick's Disease Information Page http://www.isl.net/~hoffcomp/picks.html Coping With Pick's - Links http://www.bhoffcomp.com/coping/picks.html What is Lewy Body Disease? http://www.zarcrom.com/users/alzheimers/odem/lewy00.html Lewy Body Disease - Not Exactly Alzheimer's or Parkinson's Disease http://www.alzsf.org/research/resrchlewy.html Diffuse Lewy Body Disease Presenting as Multiple System Atrophy http://canjneurolsci.org/26maytoc/diffuse.html Dementia with Lewy Bodies http://www.neuro.nwu.edu/meded/behavioral/lewy.html Research activities http://www.prit.go.jp/en/ulhi/ulhie.html Corpus Callosum Atrophy and Cognitive Impairment in Corticobasal Degeneration http://members.tripod.com/~ThJuland/corpus-callosum.html http://www.albany.net/~tjc/corpus-callosum.html Comparative Biochemistry of Tau in Progressive Supranuclear Palsy, Corticobasal Degeneration, FTDP-17 and Pick's Disease http://brainpathology.upmc.edu/vol9/0904/0904a6.htm Role of tau proteins http://www.alzforum.org/members/forums/amsterdam/news/mechanisms_2.html Support Groups & Patient-to-Patient Services MGH Neurosurgical Service MGH Neurology Department http://neurosurgery.mgh.harvard.edu/SptGps.htm Let me know if you require anything else... Best wishes ............ murray [log in to unmask]