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Hi Jackie & Bob, I have no medical credentials. I am a mechanic who happens to have Parkinson's. My opinion is just an opinion. You asked for help. I've seen little from the "pro's." I read your post, looked up the monographs for the meds. Bob is taking, and these are my thoughts on this matter.... There appears to be great potential for serious negative interactions. Compazine is contraindicated for Parkinsonians. Dalmane is contraindicated for continuous use. With twelve meds. taken in combination I fear for the eventual result. Get a second opinion from a movement disorder (Parkinson's) specialist as soon as possible. Time is of the essence here. Do not wait. Tell your prescriber or health care professional about all other medicines that you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also, tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines. Physicians using antidepressant and antipsychotic drug therapy should be aware of the potential interaction and assess the risk-benefit profile of the specific medications. ARTANE (Anticholinergic, Antispasmodic, Adjunct therapy w/Levadopa in Parkinsonism) Trihexyphenidyl Hydrochloride - Brand name: Artane Drug monograph http://www.mentalhealth.com/fr30.html http://www.rxmed.com/monographs/artane.html http://www.healthsquare.com/pdrfg/pd/monos/artane.htm http://www.ionet.net/~jcott/homepage/drugdb/133.html COMPAZINE (antiemetic, antipsychotic, tranquilizer) SmithKline Beecham Prochlorperazine maleate - Brand name: Compazine Drug Monograph http://www.sb.com/products/index.html http://www.healthsquare.com/rx/compazin.htm http://www.healthsquare.com/pdrfg/pd/monos/compazin.htm http://www.planetrx.com/product/rx/shelf/add_info/1901_introduction.html http://parkinson.org/medD2.htm http://www.ionet.net/~jcott/homepage/drugdb/108.html DALMANE (Hypnotic Agent, Sedative) Flurazepam - Brand name: Dalmane Drug monograph http://www.mentalhealth.com/fr30.html http://www.rxmed.com/monographs/dalmane.html http://www.healthsquare.com/pdrfg/pd/monos/dalmane.htm MS CONTIN (Opioid Analgesic) Morphine Sulphate - Brand name: MS Contin Drug monograph http://www.rxlist.com/cgi/generic/ms_ad.htm#DI http://www.rxmed.com/monographs/morph3.html PAXIL (Antidepressant) SmithKline Beecham Paroxetine hydrochloride - Brand name: Paxil® Drug monograph http://www.rxmed.com/monographs/paxil.html http://www.sb.com/products/index.html http://www.psyweb.com/Drughtm/paxoxe.html http://www.healthsquare.com/pdrfg/pd/monos/paxil.htm http://www.ionet.net/~jcott/homepage/drugdb/097.html QUININE (Antimalarial agent) Quinine Sulfate - Brand name: Quinine Drug Monograph http://www.rxmed.com/monographs/quinine2.html ROXICET (narcotic analgesic) Acetaminophen; Oxycodone Hydrochloride - Brand name: (Endocet™, Percocet®, Roxicet™, Roxilox™, Tylox® ) Drug Monograph http://www.healthsquare.com/pdrfg/pd/monos/percocet.htm http://my.webmd.com/content/asset/cp_drug_28 http://www.onhealthnetworkcompany.com/conditions/resource/pharmacy/Multum0/item,69615.asp SEROQUEL (Antipsychotic) Quetiapine fumarate - Brand name: Seroquel Drug monograph (1997) http://www.mentalhealth.com/fr30.html http://pharminfo.com/pubs/msb/quetiapine241.html http://www.usa.zeneca.com/products/cns.asp#seroquel SENOKOT (Peristaltic Stimulant, Stool softener, Laxative) Senna Glycosides - Brand name: Senokot Drug Monograph http://www.rxmed.com/monographs/senos.html SINEMET (Antiparkinson Agent) Levodopa; Carbidopa - Brand name: Sinemet Drug Monograph http://www.rxmed.com/monographs/sinemet.html http://www.ionet.net/~jcott/homepage/drugdb/028.html SINEMET CR (Antiparkinson Agent) Levodopa; Carbidopa - Brand name: Sinemet CR Drug Monograph http://www.rxmed.com/monographs/sinemet2.html http://www.healthsquare.com/pdrfg/pd/monos/sinemet.htm http://www.ionet.net/~jcott/homepage/drugdb/028.html VALIUM (Antianxiety, Muscle relaxant, Sedative) Diazepam - Brand name: T-Quil, Valium Drug monograph http://www.mentalhealth.com/fr30.html http://www.rxmed.com/monographs/valium2.html http://www.healthsquare.com/pdrfg/pd/monos/valium.htm http://www.ionet.net/~jcott/homepage/drugdb/045.html I wish you the best of healthy choices .......... murray On 6 May 2000, at 9:37, Jackie G. wrote: > My husband, Bob, (age 49) diagnosed eight years ago, had a Pallidotomy > (rt. brain) 1997, has been on a steady decline sine his DBS STN (rt. > brain also) in January, 2000. He is now in Hospice at home. > > Aside from the fact that he can hardly move anything, he is in terrible > pain... in his calves, thighs, feet, back, neck and arms. He has > difficulty swallowing his pills so I give them in applesauce. > > He is currently taking: > MS Contin 15 mg every 12 hours > Compazine 10 mg > Roxicet 5/325 every 4 hours as needed > Valium 5 mg, twice a day > Artane 5 mg, 3 x a day > Paxil once a day > Seroquel 25 mg. 2 at bed > Senecot 2 in morning, 2 at bed > Quinine 325 mg 2 at bed > Dalmane 15 mg. 2 at bet > > -2 reg 25/100 Sinemet > -3 CR 25/100 Sinemet > - the above at various times throughout the day. > > Obviously the pain meds are not working as he is in such tremendous > pain, I must constantly pick him up (200 lbs) and move him to a > different position, usually to the wheelchair, sofa and back to the > hospital bed again, we do this over and over all day and all night long. > If we are lucky he sleeps 3 straight hours, usually 1 - 2 hours and > again wakes up from the muscle cramps. > > Needless to say this is an extremely difficult time (I feel especially > sad for our 15 yr. old daughter who is living is this horrible ordeal). > The doctors are puzzled by Bob's pain - they do not know why he is in > such pain therefore they are reluctant to prescribe any stronger pain > meds, so yesterday they added the Valium. To me and Bob last night his > cramps seemed to be worse than before the Valium. > > If anyone has any ideas or thoughts we would appreciate it. > Sincerely, > Jackie Gilman > [log in to unmask]