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Carole - what a great reply to Audrey regarding depression. Doggonit, we've all been there at sometime or another. I can't take antidepresssants because of the various side effects, but some do and it works on them in a great way. Some people respond in 4 to 5 days, and some take a week or two for it to kick in. And I'm grateful that it works for some. Best wishes, Jo Ann from Houston