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Ray and all,

I keep thinking that the virus theory for PD's cause
makes SO much sense !  Maybe what you have
provided below about the Epstein-Barr virus will help
unravel the mystery.

If you have to suffer through this, Ray, I hope
you don't go through what some of us who have
been getting worn out have to go through.

Ivan
50/39/36



On Thu, 11 May 2000 01:04:44 -0500 =?iso-8859-1?Q?=2A?=
<[log in to unmask]> writes:
> Hi All:
>
> Epstein-Barr virus was cultured in the Rochester, NY lab (were I
> used to work).
> 12 years prior to PD diagnosis.
>
> I'll be curious to follow this research.
>
> Ray
>
>
>
>
> > E-MOVE reports from the 52nd Annual Meeting of the American
> Academy of
> > Neurology, held in San Diego, California, 30 April-5 May 2000.
> Citation
> > numbers below refer to abstracts of presentations and posters,
> which are
> > published in Neurology 2000;54(suppl.3).
> >
> > Epstein-Barr virus latent membrane protein immunoreactivity in Lewy
> > bodies: An example of molecular mimicry between EBV and
> alpha-synuclein
> > JM Woulfe, DG Munoz
> > P01.136
> >
> > An antibody against Epstein-Barr virus reacts with alpha-synuclein,
> > according to this study.
> >
> > A monoclonal antibody was generated against Epstein-Barr virus
> latent
> > membrane protein (EBV- LMP). Immunohistochemical analysis of
> > antibody-protein interaction in normal brain showed "identical
> topographic
> > and cellular patterns of distribution in all areas examined" for
> both the
> > EBV-LMP antibody and other alpha-synuclein markers. Within Lewy
> bodies in
> > PD brain, the pattern of distribution matched that of
> alpha-synuclein, but
> > not ubiquitin, tau, or neurofilament protein. Direct interaction
> of the
> > antibody with alpha-synuclein was confirmed by western blot and
> ELISA. The
> > authors conclude, "Assuming that similar antibodies are generated
> during
> > natural latent infection with EBV, these results could bear
> implications
> > with respect to elucidating a virally initiated, autoimmune
> pathogenesis
> > for Parkinson's disease, and, perhaps, for other ëalpha-
> > synucleinopathies.'"
> >
> >
> >
> >
> --
>
.........................................................................
.
>                     Ray Strand
>      mailto:[log in to unmask]
>                    48/47/45?
>
.........................................................................
.
>
> ...on the edge of the prairie abyss ......................

^^^^^^  WARM GREETINGS  FROM  ^^^^^^^^^^^^  :-)
 Ivan Suzman        50/39/36       [log in to unmask]      :-)
 Portland, Maine    land of lighthouses     44 raw and cold, wintry deg.
F   :-)
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