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Hi Janet , It is not schizophrenia that has an abrupt change of mood ? How about people that have double personality ? Could these have some connection with the "on-off" condition someway since they occur also in the brain ? Cheers , janet paterson wrote: > this discussion on clinical depression has triggered > something else i have been mulling about for awhile > > is pd unique in terms of its "on-off" phenomenon as compared with other 'disabilities'? > > is there any other 'chronic degenerative condition' which can change > from a virtually 'cured' appearance symptomatically > to severe incapacity several times in a day > as part of its 'normal' manifestation? > > [speaking for myself of course and any other parkie > who may be at an on-off plateau like mine] > > if this is unique to pd > i wonder what kind of impact this 'cycling' has on us psychologically? > if any? > [pun not intended, honest] > > do we go through a range of emotions [maybe subconsciously] > from "it's a miracle!! i'm cured!!" to "ono, i'm paralysed again" > and if we do that several times per day > are we exposed to extreme stress > without necessarily being > conscious of it? Joao Paulo - Salvador,BA,Brazil [log in to unmask]