My personal opinion is ::: that there are a lot of causes (see below) of PD (the
effect).
--physical trauma (boxers)
--possibly viral (encephilitis, EBV, etc...)
--genetic (Parkin gene, early onset, Wilsons Disease
--fruit fly (PD), mouse(PD WD), dogs(WD) serve as genetic models
--drugs (MPTP, 6-OHDA, amphetamines, etc... see animal models)
--pesticides (there may be a few out there)
--(Rotenone now the new model for PD induction in laboratoy animals)
--Whatever the major risk groups are, and there are several
--(from statistical epidemiology), and our neuros usually ask
What I'm getting at is all these causes are not THE cause of the PD manifest
effect.
All these events possibly "trigger" apoptosis (natural cell death) in a
persistent ongoing process that destoys the substantia nigra
(which leaves us lacking in dopamine, gives us the symptoms of PD)
(and an interest in this listserve).
Look up neuroprotectants such as these and others
--(CGP 3466B, HU-211, naphthoquinone, cannabinoids, THC 346, 6R-BH(4),
etc...)
and you will get feeling that we still don't know what bush we are beating
around.
The same applies to curative (not just symptomatic) treatments.
Various stem cell implants (animal, fetal, adult, auto), genetic theapy with
viral vectors--several, brain growth hormones, neuroimmunophilins, etc...
I hope this can all be sorted out soon.
It sometimes makes me itchy to be in a lab again.
Just ordered up a dozen papers from PubMed via the
University Library web page, for light reading on my trip out West
(Spokane area) for possibly the last Sunbanks Blues Festival
--and to see my sisters.
--
> > > authors conclude, "Assuming that similar antibodies are generated
> > > during natural latent infection with EBV, these results could bear
> > > implications with respect to elucidating a virally initiated,
> > > autoimmune pathogenesis for Parkinson's disease,
> > > and, perhaps, for other alpha-synucleinopathies
>
what is interesting is there is pattern of distribution of anti-bodies--
perhaps a different virus is involved, similar to EBV...this is just a starting
point
when it comes to viral research-but, what they are looking at is like a
bio-molecular finger print.
[log in to unmask] wrote:
> Re: exposure to or having had "mono" virus...
>
> I recall in the 60's reading an article that "mono" was a disease of the
> affluent...this was published by a researcher at the Fox Chase Cancer Center
snipped
> This, I would assume sorta blows the theory of a link between PD/mono.
>
> Rita
-- maybe--
-- as they say in the report -- "perhaps"
-- wait and see
-- we need all the clues we can get.
Yours in Hope.
..........................................................................
Ray Strand
mailto:[log in to unmask]
48/47/45?
..........................................................................
...on the edge of the prairie abyss ......................
