Thanks Janet for all these abstracts.
I realize it must take a lot of work, but I for one sure appreciate it.
Reading these abstracts gives me hope
(Or did I already say that?)
janet paterson wrote:
>
> Effect of selegiline on cognitive functions in Parkinson's disease.
>
> BACKGROUND: Selegiline hydrocholoride, a selective MAO-B inhibitor is known to improve motor functions in Parkinson's disease (PD).
>
> The present study was undertaken to study the effect of selegiline on memory and intelligence of PD patients.
>
> MATERIAL AND METHOD: 32 patients of PD were divided in two groups: selegiline group (n = 17) received 10 mg selegiline per day and control group (n = 15) did not receive selegiline.
>
> Patients receiving trihexyphenidyl and selegiline were excluded. All other treatment remained unchanged.
>
> All patients were examined at baseline and after three months for change in UPDRS score, WAIS score, memory test and P300.
>
> RESULTS: Patients in selegiline group had less severe disease (UPDRS score 24.11 +/- 14.07) as compared to controls (UPDRS score 40.53 +/- 18.52).
>
> There was significant improvement in UPDRS score (p < 0.05), WAIS (p < 0.001) and memory (p < 0.001) in selegiline group.
>
> In the control group there was a significant prolongation of P300 latency (p < 0.05).
>
> CONCLUSION: The study suggests that selegiline improves memory functions and intelligence in PD patients in addition to motor functions.
>
> It also prevents prolongation of P300 latency which is a marker of cognitive function.
>
> J Assoc Physicians India 1999 Aug;47(8):784-6
> Dixit SN, Behari M, Ahuja GK
> Department of Neurology, All India Institute of Medical Sciences, New Delhi.
> PMID: 10778622, UI: 20241090
>
> "http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10778622&dopt=Abstract"
>
> janet paterson
> 53 now / 41 dx / 37 onset
> 613 256 8340 / PO Box 171 Almonte Ontario K0A 1A0 Canada
> visit my website "a new voice" at: http://www.geocities.com/janet313/
--
Frans van Duinen
(416) 652-8580
Toronto, Ontario
