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On 5 Jun 00, at 18:48, Robin wrote: > I have 2 questions on how to improve my Mom's quality of life.... > She is now on Sinemet 25/100 and Comtan every 4 hours.... > > 1. She has almost "explosive" diarrhea or watery stool once or > twice a day.... Robin, Diarrhea can be a side effect of Comtan. How much is she taking? How was it introduced? Gradually or all at once? If it continues to be a problem, she can probably do without it. It's not essential. Comtan prolongs the effect of Sinemet, making its effects somewhat smoother. Without Comtan she may need to take the Sinemet a little more frequently and may have somewhat more dyskinesia. Best wishes, Phil Tompkins Amherst MA age 62/dx 1990