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As may be seen from the numerous current contributions on this topic, there's plenty of evidence, but a final sweeping verdict is not in. It's true, Sinemet has its drawbacks, but so do the various agonists, and perhaps in most cases the choice to go one way or the other (just like many others of life's choices) isn't so critical. Cheers, Joe -- J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks, CA 91403-5013