Hi Dave You sound a typical (although each case is so individual)new member on the block. I thik due to media everybody thinks sinemet. But the longer you keep offf it the more powerful t will be for your treatment later. The mirapex elderpryl combo, is quite common on newbies and will chamge as you progress (slowly I hope) Now 13 years with the uninvited guest PD but have progressed typically but slowly. along with 2000 vit. per day.but to my regret as treatment was accepted with sinemet at time now causing me to have reactions after 13 years, If you can be controlleed with this regimen stick withit. My meds. stil being adjusted after adding comtran Sinemet 25/100 11/2 every three hours plus elderpryl 2 mirapex 41/2 comtan 3. 2000 Vit E .1000 A+_D .Fosamax and Synthroid.Klonopin for nap attacks. Good luck and stick with it you will be the only person to be able to account the reaction to neuro Margaret Clark 48/61/13 Margaret Clark 48/61