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Dear Mr. Fleming, Dr. Gary Tollefson forwarded me your message concerning Permax....I am the Global Marketing Manager for Permax....discovering and developing new effective treatments for Parkinson's Disease is an on-going process for Eli Lilly &Co......Currently all efforts are in their very early stages of development....In addition, we are continually looking for discoveries and opportunities with our many partners in Neuroscience Discovery....I hope that your symptoms are being managed effectively with your current treatments.....Your question about the patent for Permax:, the patent for Permax expired in February of 2000...The manufacturing process for Permax is very expensive and complicated....I am not aware of any generic pergolide available anywhere in the world... I want to thank you for your continued committment and support of Eli Lilly and Co...Best wishes to you in the future....Sincerely, Stepehen L Page