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"Teresa V. Bohuszewicz" wrote: > I know that Comtan binds with the COMT enzyme so that the enzyme is not able > to bind with levodopa. What normally binds with the enzyme that is now > taken over by the Comtan? In other words if a PWP is not taking Comtan or > levodopa what would be the purpose of the COMT enzyme? Im memory serves me, (getting dicey) COMT is one of the body's two major guardians againse excess production of amphetamine (Adrenaline) which is part of the "fight or flight" reaction when needed. The other is monoamine oxidase. That's why the PIs for selegiline (a MAO inhibitor) tolcapone, and entacapone (COMT inhibitors) warn against taking a COMT inhibitor and a MAO inhibitor at the same time, it could provoke a hypertensive crisis. Cheers, Joe -- J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks, CA 91403-5013