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Teresa, I am not aware of physical weakness as being a reported side effect of Comtan. Even if it hasn't been reported I think that the Comtan could be the culprit (although I doubt it would be for the reasons you mention). The worsening of her condition since starting the Comtan and specifically the weakness is possibly bad reaction to the Comtan or may be "just" her PD progressing. Make sure her doctor is aware of your opinion that she has gotten weaker since starting the Comtan. Good luck, Charlie ----- Original Message ----- From: "Teresa V. Bohuszewicz" <[log in to unmask]> To: <[log in to unmask]> Sent: Saturday, June 10, 2000 9:06 AM Subject: Another question on COMT Enzyme > Thank you for your responses to my question about the purpose of the COMT > enzyme. > > If the COMT enzyme is a guardian against excess production of epinephrine > (adrenaline) would a possible side-effect be lack of energy and/or increased > physical weakness? > > Mama has been very gradually increasing her intake of Comtan for several > weeks and has been getting weaker and weaker. She has been taking Comtan > and Sinemet during the day and nothing during the night. (She doesn't need > medication at night.) She is strongest in the early morning before > medication but gradually deteriorates as the day progresses...to the point > that she cannot stand up from a chair without help. Of course, even though > she is strongest early in the morning she is not as strong as she was when > she was taking Sinemet alone prior to the introduction of Comtan. > > From the very beginning when we gave her Comtan she has complained of > physical weakness but my father and I managed to convince her to stick with > it to obtain a long enough history with this medication. > > Her Sinemet intake is less now with the Comtan but when we give her more > Sinemet to combat the physical weakness brought on by the Comtan she > experiences worse dystonias. > > So, is a side-effect of Comtan use a lack of physical strength? > > Teresa, Daughter of Mama (58/43/38) >