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i am taking sinemet i/2 a CR 25/100 every 2 houirs, comtan with every ohter sinemet dose, up to 6 x a day (usually only' 4e during the day and i skip the comtan during the night) and i am in the process of changing from mirapex to requip - i have phased out mirapex, and and i am still phasing in the requip. My doctr believes in doing th is ver gr adually, eve nat the rsk of somediscomfort / At first my sinemet requirement dropped amazinglly , but it has gradually drept back up to where it was before the comtan.so i am not quite sure yet if i hiave gained anything. However i have been under a lot of strain (personal relationships and selling my house and buying a condo) I have just signe d a contract, and my private life seems back on a more even keel, so lets see if that has played a part by seseing what the next few weeks bring! hilary blue Grace M McNamara wrote: > > Connie and List, > We were told to take comtan with Sinemet (Carbido/Levo). > My husband takes Comtan 200 mg. with his 25/100 Carbido/Levo at > approximately 7:30, 11:30 and 4:30. At 10:30 PM he takes his Sinemet > alone. He has been on this for about three months. He seems to be > getting worse. Weaker, slower movement and some shaking. > We are going back to Eldepryl once a day, and dropping the comtan. His > doctor is thinking about putting him on Mirapex or Requip. Does anyone > think one is better than the other. > > Grace cg for George 71-63-60