Greg... Over the 25 years I've had PD, I've heard various MDs state that going off Sinemet can be "bad," due to the drug causing physical changes in the brain. Despite my asking just what "BAD" means in my case, no one doctor would ever satisfactorily (to me) define just what they mean by "bad." Kinda makes ya wonder, doesn't it? Barb Mallut [log in to unmask] -----Original Message----- From: Greg and/or Diane Sterling <[log in to unmask]> To: [log in to unmask] <[log in to unmask]> Date: Sunday, June 18, 2000 10:50 AM Subject: Sinemet causes neuro damage I just read Dr. Gott's medical advice column in the Sunday paper. His topic this week is Restless Leg Syndrome. He states that it may be related to PD which I have heard before. The following statement he made shocked me and I was wondering if anyone on the List had information supporting this, or is Dr. Gott misinformed. The statement is that "Sinemet is a cause of permanent neurological damage". Greg 47/35/35