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have you tried to minimize the amount of carbidopa that you take? use only 10/100 tablets? just ron -- Ron Vetter 1936, '84 PD dz mailto:[log in to unmask] http://www.ridgecrest.ca.us/~rfvetter Hi "just Ron", I only take (4) 25/100 tablets of Sinemet daily, sometimes I forget to take them and only take 3. One before each meal. I refuse to set my wristwatch timer and become a slave to my PD by having to take medication every 2 hours, its just my own thing, but I couldn't,nor would I want to live that way. I WON'T let it conquer me!!! So, according to my ND its the total amount I take, and I take the least amount possible. I don't take anything else, no requip, no miraplex, no eldepryl, nada!!! I have found out over the years, the least amount of medication I take, the better off I am. But thanks for your suggestion, and taking the time to answer. As Ever, just me, Marjorie