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Mario: I can't answer your question about the Xanax but Mama takes Sinemet 8 times a day and has found that Xanax allows the Sinemet to work very, very well for most of the day. Her neurologist was surprised by that. But because Xanax is addictive Mama only takes Xanax once in a while when she really needs it. (Many years ago she started taking Xanax regularly and found that over time it lost its effectiveness, hence, her reasons for now only taking it when absolutely needing it.) Teresa